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1st International Conference on Polyploid Giant Cancer Cells: Biology and Clinical Applications


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1st International Conference on Polyploid Giant Cancer Cells: Biology and Clinical Applications Banner

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Add to Calendar 1st International Conference on Polyploid Giant Cancer Cells: Biology and Clinical Applications 2/16/2024 8:00:00 AM 2/17/2024 4:00:00 PM America/Chicago For More Details: https://mdanderson.cloud-cme.com/Polyploid2024 Description: We cordially invite Scientists, Oncologists, Post-Doctoral Fellows, and Graduate Students engaged in cancer research to join us for the inaugural International Conference on Polyploid Giant Cancer Cells.Over the past century, pathologists have observed distinctively large mononucleated or multinucleated giant cancer cells, termed polyploid giant cancer cells (PGCCs). These cells, characterized by multiple copies of... MD Anderson - Duncan Building false MM/DD/YYYY


Date & Location
Friday, February 16, 2024, 8:00 AM - Saturday, February 17, 2024, 4:00 PM, MD Anderson - Duncan Building, Houston, TX

Target Audience
Specialties - Medical Oncology, Pathology, Pathology - Anatomic, Radiation Oncology
Professions - Other, Physician (MD or DO), Student or Trainee

Credits
AMA PRA Category 1 Credits™ (11.25 hours), Non-Physician Attendance (11.25 hours)

Overview

We cordially invite Scientists, Oncologists, Post-Doctoral Fellows, and Graduate Students engaged in cancer research to join us for the inaugural International Conference on Polyploid Giant Cancer Cells.

Over the past century, pathologists have observed distinctively large mononucleated or multinucleated giant cancer cells, termed polyploid giant cancer cells (PGCCs). These cells, characterized by multiple copies of the genome, significantly contribute to nuclear atypia—a crucial diagnostic criterion in cancer grading and malignancy assessment.
Detected in approximately 37-50% of human cancers, polyploid genomes represent one of the most prevalent genetic alterations in cancer. PGCCs, prevalent in high-grade malignant tumors across various organs—such as the breast, ovary, uterus, pancreas, colon, lung, brain, and in leukemia, lymphoma, and sarcoma—are now a subject of extensive study.

Previously considered senescent and nonviable due to their inability to undergo mitosis, recent years have witnessed a transformative shift in understanding PGCCs. These cells represent a stress-responsive mechanism, demonstrating mitosis-independent growth resembling early embryogenesis. This characteristic impacts immortality, malignant transformation, invasion, metastasis, dormancy, and resistance. Their embryonic properties have revitalized century-old embryonic cancer theories, reshaping our comprehension of cancer on organismal and tissue-development levels

The emerging study of PGCCs holds significant promise for understanding cancer and improving patient outcomes by enhancing therapeutic efficacy, reducing resistance, and enabling early detection. The dedicated special issue on PGCCs in underscores the paramount importance of this field. www.sciencedirect.com

 

Conference Chair, Jinsong Liu, MD,PhD and Conference Co-Chair, Donna Hansel, MD, PhD 

 

This international conference aims to gather cancer scientists, pathologists, and clinicians in this burgeoning field to discuss current insights and disseminate ideas. Together, we aspire to translate findings into clinical practice and save lives from cancer. This is a crucial step in ensuring that scientific research is effectively applied to the diagnosis, treatment, and care of cancer patients.


Objectives
At the conclusion of this activity, learners will be able to:

  1. Describe how PGCCs relate to both embryogenesis and cancer progression.
  2. Evaluate the potential of PGCCs in early cancer detection, diagnosis, and therapy resistance.
  3. Investigate and learn brand-new concepts about this emerging field of cancer biology.

Registration
1st International Conference on Polyploid Giant Cancer Cells: Biology and Clinical Applications - February 16, 2024. The conference will begin at 8:30 AM, and will adjourn at 3:35PM, Saturday, February 17.  Location: Dan L. Duncan Building, 1155 Pressler St. Floor 8, Houston, TX 77030, Conference Center Rooms 1-8
  •  Registration fee includes tuition for this in-person Live Activity.
  •  The deadline for advanced registration is January 16, 2024.
Registration Category Fee: 
 

 

We accept the following forms of payment:

  • Credit Cards (MasterCard, VISA, and American Express)
  • Check (Payable to The University of Texas MD Anderson Cancer Center; through U.S. banks only)

Mail checks to:
Continuing Professional Education – Unit 1781
The University of Texas MD Anderson Cancer Center
P.O. Box 301407
Houston, Texas 77230-1407

When registering online a receipt (confirmation letter) will be automatically emailed to the e-mail address you list on the registration form. 
Telephone registrations are not accepted.

Special Assistance:
Contact Continuing Professional Education / Activity Management at 713-792-2223 or 866-849-5866. You may also email CPE at [email protected].

Refund/Cancellation Policy: 
The registration fee, minus a $25 administration-handling fee, is refundable if a written request is received on or before February 2, 2024. No refunds will be granted after these dates. The request for a registration refund must include the tax identification number of the company or institution if registration was paid by a company or institution check. 
 
Continuing Professional Education (CPE), reserves the right to cancel activities prior to the scheduled date, if low enrollment or other circumstances make it necessary.  Each registrant will be notified by mail, e-mail, or at the phone or fax numbers given on the registration form. In case of activity cancellation, the liability of the CPE is limited to the registration fee. CPE will refund the full registration fee. 
 
CPE reserves the right to limit the number of participants in an activity and is not responsible for any expenses incurred by an individual whose registration is not confirmed and for whom space is not available. 

 

Ground Transportation:
Houston is served by two airports, George Bush Intercontinental (IAH) and William P. Hobby (HOU).  The following ground transportations are available to and from the airports to the Medical Center.

     • Uber and Lyft
     • Taxicabs: Yellow Cab 713-236-1111; Fiesta Cab 713-225-2666.
     • Super Shuttle: For more information, call toll free at 800-258-3826, or on-line at www.supershuttle.com.

Evaluation:
A course evaluation tool will provide participants with the opportunity to comment on the value of the program content to their practice decisions, performance improvement activities, or possible impact on patient health status. Participants will also have the opportunity to comment on any perceived commercial bias in the presentations as well as to identify future educational topics.  The survey link will be provided during the review course.

 

For additional information or Special Assistance, contact CPE at 713-792-2223 or toll free at 866-849-5866 or via e-mail: [email protected].

 


Accreditation

In support of improving patient care, The University of Texas MD Anderson Cancer Center is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

Credit Designation: 
The University of Texas MD Anderson Cancer Center designates this live activity for a maximum of 11.25 AMA PRA Category 1 CreditsTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.



Additional Information

View the accessibility policy for The University of Texas M.D Anderson Cancer Center.

 


The registration form for this activity is currently unavailable.

You will find the information for your online reservation link below. If you have questions or need help with the link, please do not hesitate to ask. We appreciate your business and look forward to a successful stay.

Book your group rate for Polyploid Giant Tumor Cancer Conference Room Block 

Event Summary:
Polyploid Giant Tumor Cancer Conference Room Block
Start Date: Thursday, February 15, 2024
End Date: Sunday, February 18, 2024
Last Day to Book: Thursday, January 18, 2024

Group Code: PGTPGTR

Hotel offering your special group rate:
Houston Marriott Medical Center/Museum District for 159 USD per night

Book your group rate for Polyploid Giant Tumor Cancer Conference Room Block

 

Additional Hotel Options: 

Hilton Houston Plaza/Medical Center
6633 Travis Street
Houston TX  7030
713-313-4000
Hilton Houston Plaza/Medical Center
Room Rate:  Varies

DoubleTree by Hilton Houston Medical Center Hotel & Suites
6800 Main Street
Houston, TX  77030
713-528-7744
DoubleTree by Hilton Medical Center
Rom Rate:  Varies

Hilton Garden Inn Houston Medical Center
6840 Almeda Rd.
Houston, Texas 77030
346-433-8200
Hilton Garden Inn Houston Medical Center
Rom Rate:  Varies



The University of Texas MD Anderson Cancer Center complies with all requirements of the identified accrediting body  (ACCME, ANCC, ACPE). Disclosure of speakers, faculty members, planning committee members and their commercial relationships will be shared with learners prior to the educational activity.



Mitigation of Relevant Financial Relationships


The University of Texas MD Anderson Cancer Center adheres to the ACCME's Standards for Integrity and Independence in Accredited Continuing Education. Any individuals in a position to control the content of a CE activity, including faculty, planners, reviewers or others are required to disclose all financial relationships with ineligible companies (commercial interests). All relevant conflicts of interest have been mitigated prior to the commencement of the activity.

Member Information
Role in activity
Nature of Relationship(s) / Name of Ineligible Company(s)
Donna E Hansel, MD, PhD
Division Head
UT MD Anderson Cancer Center
Co-Director, Faculty
Advisor-AstraZeneca US
Jinsong Liu, MD, PhD
Professor
The University of Texas MD Anderson Cancer Center
Course Director, Faculty
Nothing to disclose
Sujuan Ba, PhD, President & CEO of NFCR
Dr.
National Foundation for Cancer Research (NFCR)
Faculty
Nothing to disclose
Robert C Bast Jr., MD
Director of Translational Research Career Development
MD Anderson Cancer Center
Faculty
Royalties or Patent Beneficiary-Fujirebio Diagnostics Inc
Amy Bowes, MBBS
Dr
The Francis Crick Institute
United Kingdom
Faculty
Nothing to disclose
Brian R Calvi, PhD
Professor
Indiana University
Faculty
Nothing to disclose
Yu-Chih Chen, PhD
Assistant Professor
UPMC Hillman Cancer Center/University of Pittsburgh
Faculty
Nothing to disclose
Michelle R Dawson, PhD
Assistant Professor
Brown University
Faculty
Nothing to disclose
Wu-Min Deng, PhD
Professor
Tulane Univeristy
Faculty
Nothing to disclose
Giulio Draetta, MD, PhD
SrVP, Chief Scientific Officer
The University of Texas MD Anderson Cancer Center
Faculty
Nothing to disclose
Jekaterina Erenpreisa, Dr hab. med.
Leading researcher
Latvian Biomedical Research and Study Centre
Latvia
Faculty
Nothing to disclose
Daniel J Gironda, BA
PhD Candidate
Wake Forest University School of Medicine
Faculty
Nothing to disclose
Funan He, PhD
University of Texas Health Science Center, San Antonio
Faculty
Nothing to disclose
Henry Heng, PhD
Professor
Wayne State University
Faculty
Nothing to disclose
Georges Herbein, MD, PhD, FRSM
Professor
Université of Franche-Comté
France
Faculty
Nothing to disclose
James G Jackson, PhD
Associate Professor
Tulane
Faculty
Nothing to disclose
Philip Jones, PhD
VP Therapeutics Discovery, Research Strategy and Operations
MD Anderson Cancer Center
Faculty
Nothing to disclose
Stavroula CD Kousteni, PhD
Professor
Columbia University Medical Center
Faculty
Nothing to disclose
Xiaoran Li, PhD
Postdoctoral fellow
MD Anderson Cancer Center
Faculty
Nothing to disclose
Perry Marshall, BS
Reversing Cancer
Faculty
Nothing to disclose
Nicholas Navin, PhD
Dr.
MD Anderson Cancer Center
Faculty
Nothing to disclose
Kenneth J Pienta, MD
Dr.
Johns Hopkins
Faculty
Nothing to disclose
Azra Raza, MD
Professor of Medicine, Director
Columbia University
Faculty
Membership on Advisory Committees or Review Panels, Board Membership, etc.-Epizyme, Inc.
Bruno Sainz Jr., PhD
Dr.
Instituto de Investigaciones Biomédicas Sols-Morreale (IIBM) - CSIC-UAM
Faculty
Nothing to disclose
Subrata Sen, PhD
Professor
UTMD Anderson Cancer Center
Faculty
Nothing to disclose
Anil Sood, MD
Professor
MD Anderson Cancer Center
Faculty
Paid consultant-Merck Sharp & Dohme Corp. (any division) (Relationship has ended)|Paid consultant-AstraZeneca US (Relationship has ended)|Paid consultant-Kiyatec (Relationship has ended)|Paid consultant-Onxeo|Paid consultant-ImmunoGen (Relationship has ended)|Other: Meeting sponsored by this company-Verastem (Relationship has ended)|Royalties or Patent Beneficiary-Top Alliance (Relationship has ended)|Stocks or stock options, excluding diversified mutual funds-Bio Path Holdings, Inc.
Vural Tagal, PhD
Dr.
H. Lee Moffitt Cancer Center and Research Institute
Faculty
Nothing to disclose
Dean Tang, PhD
Chair and Professor
Roswell Park Comprehensive Cancer Center
Faculty
Nothing to disclose
Christina Voelkel-Johnson, PhD
Associate Professor
Medical University of South Carolina
Faculty
Nothing to disclose
Melissa H Wong, PhD, Co-leader, Cancer Biology Program, OHSU Knight Cancer Institute, School of Medicine
Vice Chair & Professor
Oregon Health & Science University
Faculty
Nothing to disclose
Tao P Wu, PhD
Baylor College of Medicine
Faculty
Nothing to disclose
Xiang-Xi Mike Xu, PhD
Professor of Cell Biology
University of Miami
Faculty
Nothing to disclose
Mingjian James You, MD, PhD
Professor
The University of Texas MD Anderson Cancer Center
Faculty
Nothing to disclose
Dihua Yu, MD, PhD
Professor and Chair Ad Interim
The University of Texas MD Anderson Cancer Center
Faculty
Nothing to disclose
Rugang Zhang, Ph.D.
The University of Texas MD Anderson Cancer Center
Faculty
Nothing to disclose
Jian Hu, PhD
Associate Professor
UT MD Anderson Cancer Center
Faculty, Other Planning Committee Member
Nothing to disclose
Steven Lin, MD, PhD
Professor
MD Anderson Cancer Center
Faculty, Other Planning Committee Member
Membership on Advisory Committees or Review Panels, Board Membership, etc.-AstraZeneca US|Grant or research support-Beyond Spring Pharmaceuticals|Grant or research support-STCube Pharmaceuticals|Grant or research support-Nektar Therapeutics|Advisor-Creatv Microtech|Consulting Fee-XRAD Therapeutics
Jeffrey Mize, CPA
MD Anderson Cancer Center
Other Planning Committee Member
Nothing to disclose

Friday, February 16, 2024
Registration/Breakfast
8:00AM - 9:30AM
Opening Remarks
9:30AM - 9:40AM
Giulio Draetta, MD, PhD
Overview of PGCC Conference: Birth of New Field of Cancer Research
9:40AM - 10:00AM
Jinsong Liu, MD, PhD
PGCCs: Historic Aspects and Pathologic Observation
10:00AM - 10:20AM
Donna E Hansel, MD, PhD
 
Session 1: Cancer Evolution

Moderators: Henry Heng, PhD and Perry Marshall, BS
PGCCs in Two-Phased Evolution: How Transitional Supersystems Emerge from Information Self-Creation Under Crisis
10:20AM - 10:45AM
Henry Heng, PhD
Punctuated Chromosome Evolution in Breast Cancer and Beyond
10:45AM - 11:10AM
Nicholas Navin, PhD
Cancer Attractors in Evolution of Human Genome
11:10AM - 11:35AM
Jekaterina Erenpreisa, Dr hab. med.
Profiling the Genomic Landscape of Polyploid Giant Cancer Cells in Sarcomas: Hopeful Monsters or an Evolutionary Dead End?
11:35AM - 11:50AM
Amy Bowes, MBBS
Genomic Instability Shapes Whole-Genome Doubling in Cancer Evolution
11:50AM - 12:05PM
Funan He, PhD
Lunch/Poster Session
12:05PM - 1:30PM
 
Session 2: Models for PGCCs

Moderator: Subrata Sen, PhD
Polyploidy in Drosophila Tumor Models
1:30PM - 1:55PM
Wu-Min Deng, PhD
Using Model Organisms to Define the Effects of Unscheduled Polyploidy on Tissue and Tumor Growth
1:55PM - 2:20PM
Brian R Calvi, PhD
Defective Lipid Metabolism Drives Genomic Instability in Glioblastoma
2:20PM - 2:45PM
Jian Hu, PhD
Break
2:45PM - 3:00PM
 
Session 3: Cell transformation

Moderators: Dihua Yu, MD, PhD and Tao Wu, PhD
Exploring PGCCs Emerging Role in Cytomegalovirus Infection
3:00PM - 3:25PM
Georges Herbein, MD, PhD, FRSM
PGCCs in Leukemia Transformation
3:25PM - 3:50PM
Stavroula CD Kousteni, PhD
The Fecundity Structure of Polyploid Giant Cancer Cells: The Discovery, Biological Properties, and its Implication in Disease
3:50PM - 4:05PM
Xiaoran Li, PhD
Break
4:05PM - 4:20PM
 
General

Moderator: Donna Hansel, MD, PhD and Dean Tang, PhD
Life Cycle of PGCCs: Toward a Unified Understanding of Embryogenesis, Tumorigenesis, and Therapeutic Resistance on the Organismal Level
4:20PM - 5:10PM
Jinsong Liu, MD, PhD
Group Photo
5:10PM - 5:40PM
Welcome Reception and Dinner
5:40PM - 8:00PM
Saturday, February 17, 2024
 
Session 4: The Emergence of Resistance

Moderators: Anil Sood, MD and M. James You, PhD
Breakfast
7:30AM - 8:30AM
Physical and Metabolic Aspects of Therapy Induced Senescence and Polyploidy in an Evolving Tumor Microenvironment
8:30AM - 8:55AM
Michelle R Dawson, PhD
The Endocycling Cancer Cell State Mediates Cancer Lethality
8:55AM - 9:20AM
Kenneth J Pienta, MD
The Phagocytic Phenotype of Tumor Cells Made Senescent by Chemotherapy
9:20AM - 9:45AM
James G Jackson, PhD
Retrotransposable Elements Mediate the Drug-Tolerant Persistence in Chemo-Treatment
9:45AM - 10:00AM
Tao P Wu, PhD
Genotoxic Resistance in?Pancreatic Ductal Adenocarcinoma is Driven by a Programmed?Process Combining Polyploidism, Senescence and Stemness
10:00AM - 10:15AM
Bruno Sainz Jr., PhD
Break
10:15AM - 10:35AM
 
Session 5: Novel Targets for Therapy

Moderators: Rugang Zhang, PhD and Azra Raza, MD, PhD
Polyploid Giant Cancer Cells in Hematologic Malignancies as Potential Therapeutic Targets
10:35AM - 11:00AM
Azra Raza, MD
Potential Therapeutic Strategies to Interfere with Stress-Induced Polyploidization and Depolyploidization
11:00AM - 11:25AM
Christina Voelkel-Johnson, PhD
Nuclear Envelope Alterations in Carcinogenesis and Chemo-Resistance
11:25AM - 11:40AM
Xiang-Xi Mike Xu, PhD
Characterizing, Targeting and In-Silico Modeling Polyploid Giant Cancer Cells (PGCCs) in Lung and Breast Cancers
11:40AM - 11:55AM
Vural Tagal, PhD
Discovering Inhibitors of Polyploid Giant Breast Cancer Cells Using Single-Cell Morphological and Transcriptome Analysis
11:55AM - 12:10PM
Yu-Chih Chen, PhD
Lunch
12:10PM - 1:15PM
 
Session 6: Polyploid-Macrophage Fusion in Early Detection, Metastasis, and Prognosis

Moderators: Robert C. Bast, MD and Elizabeth Hansel, MD, PhD
Macrophage-Tumor Cell Fusion: Impact on Tumor Progression, Early Detection, and Measure of Treatment Response
1:15PM - 1:40PM
Melissa H Wong, PhD, Co-leader, Cancer Biology Program, OHSU Knight Cancer Institute, School of Medicine
Diagnostic and Prognostic Value of Circulating Cancer Associated Macrophages like Cells in Lung Cancer
1:40PM - 2:05PM
Steven Lin, MD, PhD
Hypertrophy of Polyploid Cancer Associated Macrophage-Like Cells in Circulation Correlates with Multi-Organ Metastatic Spread in Human Solid Tumors
2:05PM - 2:30PM
Daniel J Gironda, BA
 
General

Moderators: Sujuan Ba, PhD and Philip Jones, PhD
Open Discussion and Future of PGCCs
2:30PM - 3:30PM
Brian R Calvi, PhD
Michelle R Dawson, PhD
Henry Heng, PhD
Georges Herbein, MD, PhD, FRSM
Azra Raza, MD
Melissa H Wong, PhD, Co-leader, Cancer Biology Program, OHSU Knight Cancer Institute, School of Medicine
Jinsong Liu, MD, PhD
Philip Jones, PhD
Sujuan Ba, PhD, President & CEO of NFCR

Open Discussion and Future of PGCCs 

  • Conceptual Revolution in Cancer Research
  • Platform to Identify Anti-PGCCs Drugs    
  • Clinical Trials with Anti-PGCCs Agents  
  • Early Detection and Prognosis

Other topics to be determined


Closing Remarks
3:30PM - 3:35PM
Jinsong Liu, MD, PhD


Contact Us:
Cicely Simon
The University of Texas MD Anderson Cancer Center
7007 Bertner Avenue, Ste. 1MC16.2343
Houston, TX 77030
Email: [email protected]


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Exhibitor Packages

Exhibitor Package - Gold Price: $10000.00
Includes:
  • 6ft. Tabletop Display (Draped) with Two Chairs
  • Number of Exhibitor Badges: 5
  • Complimentary Meals (Available with Exhibitor Badge)
  • Exhibit Location: Premium Assigned

Deadline for order commitment is 2/12/2024 12:00:00 AM.

Exhibitor Package - Silver Price: $7500.00
Includes:
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  • Number of Exhibitor Badges: 4
  • Complimentary Meals (Available with Exhibitor Badge)
  • Exhibit Location: Premium Assigned

Deadline for order commitment is 2/4/2024 12:00:00 AM.

Exhibitor Package - Bronze Price: $5000.00
Includes:
  • 6ft. Tabletop Display (Draped) with Two Chairs
  • Number of Exhibitor Badges: 3
  • Complimentary Meals (Available with Exhibitor Badge)
  • Exhibit Location: Assigned

Deadline for order commitment is 2/4/2024 12:00:00 AM.

Exhibitor Package - Exhibitor Price: $2500.00
Includes:
  • 6ft. Tabletop Display (Draped) with Two Chairs
  • Number of Exhibitor Badges: 2
  • Complimentary Meals (Available with Exhibitor Badge)
  • Exhibit Location: Not Allocated

Deadline for order commitment is 2/4/2024 12:00:00 AM.

Exhibitor Package - Additional Badge (Post Registration) Price: $400.00
Includes:
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  • Promotional Items:
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Deadline for order commitment is 2/12/2024 12:00:00 AM.

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